The NIH Centers of Biomedical Research Excellence (COBRE) support thematic, multidisciplinary centers that augment and strengthen institutional biomedical research capacity.  This is accomplished by expanding and developing biomedical faculty research capabilities and enhancing research infrastructure, including the establishment of core facilities needed to carry out the objectives of a multidisciplinary, collaborative program. The COBRE program seeks to promote the initiation and development or expansion of unique, innovative state-of-the-art biomedical and behavioral research centers at institutions in IDeA-eligible states. Research supported by this program spans the full spectrum of basic and clinical sciences and encompasses all areas of health-related investigation. The NIH recognizes that contributions from institution in IDeA-eligible states are important and essential in fulfilling the promise of the NIH research agenda.

Alabama is currently NOT eligible for NIH COBRE awards.

These centers are led by NIH-funded investigators with expertise central to the theme of the grant proposal. The centers promote collaborative, interactive efforts among researchers with complementary backgrounds, skills and expertise. In some instances, COBRE support facilitates the development of new, disease-specific research centers or augments the capability of existing centers. Researchers supported through COBRE are expected to compete independently for external peer-reviewed grant support.

Each COBRE includes:

  • A principal investigator who is an established biomedical research scientist with expertise central to the research theme of the center, has an active research laboratory, has relevant peer-reviewed funding and has administrative leadership and mentoring experience.
  • Three to five individual research projects, each supervised by a single junior investigator, that stand alone but share a common thematic scientific focus.
  • At least one mentor for each junior investigator, and a development and mentoring plan addressing how the junior investigators will transition to competitive grant support from NIH institutes and centers or other Federal or non-Federal agencies or organizations.

The COBRE program consists of three sequential five-year phases.

  1. Phase 1 aims to strengthen an institution’s biomedical research infrastructure through the establishment of a thematic multidisciplinary center and enhance the ability of investigators to compete independently for complementary NIH individual research grants or other external peer-reviewed support.
  2. Phase 2 is intended to strengthen the center through further improvements in research infrastructure and to continue development and support of a critical mass of investigators with shared scientific interests.
  3. Phase 3 provides support for maintaining COBRE research cores developed during phases 1 and 2.

This and additional information on the NIH COBRE program can be found here.

The most recent FOA for the NIH COBRE can be found here.